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The Cyclic Alternating Pattern (CAP) of EEG activity during sleep
The Cyclic Alternating Pattern (CAP) is a periodic EEG activity occurring during NREM sleep. It is characterized by cyclic sequences of cerebral activation (phase A) followed by periods of deactivation (phase B) which separate two successive phase A periods with an interval <1 min. A phase A period and the following phase B period define a CAP cycle, and at least two CAP cycles are required to form a CAP sequence.
An example of cyclic alternating pattern (CAP) in sleep stage 2. A CAP cycle is defined as a phase A period followed by a phase B period lasting a minute or less. Two or more adjacent CAP cycles define a CAP sequence.
Phase A periods are subdivided into three subtypes:
- Subtype A1: synchronized events with low impact on autonomic and somatomotor activities;
- Subtype A2: mixed synchronized–desynchronized EEG events with an intermediate influence on the autonomic and somatomotor activities; and
- Subtype A3: predominantly desynchronized EEG events with heavy effects on the autonomic and somatomotor activities.
A detailed description and definition of CAP is reported in [1]. For a complete review of the history and significance of CAP, see [2].
Despite being a physiological phenomenon, CAP is also a marker of sleep instability and can be correlated with several sleep-related pathologies. In fact, on one hand CAP can reflect a reaction of the sleeping brain to any endogenous or exogenous disturbance; on the other hand, the A phase of CAP has been interpreted as a kind of gate through which pathological events more easily occur [3]. Increased amounts of CAP are often observed in sleep-disordered breathing (SDB), as well as in insomnia [4], sleep movement disorders (periodic leg movements, or PLM [5], restless leg syndrome (RLS) [6], parasomnias like REM behavior disorder (RBD), and epileptic diseases such as nocturnal frontal lobe epilepsy (NFLE) [7]. Pathological amounts of CAP can also be found in hypersomnias of central origin such as narcolepsy [8].
The ratio between NREM CAP sleep and total NREM sleep (CAP-rate), and the different distributions of CAP A phases with respect to sleep stages can be measured in sleep centers to characterize such pathologies. These indexes can be valuable as measures of sleep quality, but the time needed to determine them has been an obstacle to their adoption in routine clinical practice, since visual scoring of CAP phases A for an entire night of sleep recording requires expertise and lengthy, attentive analysis. The development of software capable of increasingly accurate and efficient automated analysis of CAP is beginning to result in wider clinical use of CAP indexes for diagnosis of sleep pathologies and assessment of the efficacy of therapeutic interventions.
The CAP Sleep Database
The CAP Sleep Database is a collection of 108 polysomnographic recordings registered at the Sleep Disorders Center of the Ospedale Maggiore of Parma, Italy. The waveforms (contained in the .edf files of the database) include at least 3 EEG channels (F3 or F4, C3 or C4 and O1 or O2, referred to A1 or A2), EOG (2 channels), EMG of the submentalis muscle, bilateral anterior tibial EMG, respiration signals (airflow, abdominal and thoracic effort and SaO2) and EKG. Additional traces include EEG bipolar traces, according to the 10-20 international system (Fp1-F3, F3-C3, C3-P3, P3-O1 and/or Fp2-F4, F4-C4, C4-P4, P4-O2).
The 16 healthy subjects included in the study did not present any neurological disorders and were free of drugs affecting the central nervous system. The 92 pathological recordings include 40 recordings of patients diagnosed with NFLE, 22 affected by RBD, 10 with PLM, 9 insomniac, 5 narcoleptic, 4 affected by SDB and 2 by bruxism. The age and gender of the subjects are reported in a spreadsheet (gender-age.xlsx).
The recordings are named according to the subjects' pathology:
n1-n16 | No pathology (controls) |
brux1-brux2 | Bruxism |
ins1-ins9 | Insomnia |
narco1-narco5 | Narcolepsy |
nfle1-nfle40 | Nocturnal frontal lobe epilepsy |
plm1-plm10 | Periodic leg movements |
rbd1-rbd22 | REM behavior disorder |
sdb1-sdb4 | Sleep-disordered breathing |
Annotations
Expert neurologists trained at the Sleep Center provided the scoring of the sleep macrostructure, according to the Rechtschaffen & Kales rules [9], while the CAP was detected in agreement with Terzano’s reference atlas of rules [10]. All the signals were visualized and the scorings were performed using REMlogic™ software (Embla).
The scores for each recording are provided as .txt files in REMlogic report format, and also as .st files in PhysioBank-compatible format. The .txt score files have the following fields:
- Sleep stage (W=wake, S1-S4=sleep stages, R=REM, MT=body movements)
- Body position (Left, Right, Prone, or Supine; not recorded in some subjects)
- Time of day [hh:mm:ss]
- Event (either a sleep stage (SLEEP-S0..S4, REM, MT), or a phase A of CAP)
- Duration (in seconds)
- Location (the signal(s) in which the event can be observed)
A Matlab script is provided for reading the .txt score files easily. By launching ScoringReader.m, an array containing the scoring of the macrostructure, and three arrays containing the starting time of the CAP A phases, their duration and their subtype, are generated. The hypnogram is reported as 0 for wake, 1 to 4 for the sleep stages, according to R&K rules, and 5 for REM. The Matlab function CAP.m computes, starting from these variables, the CAP time and CAP rate according to Terzano’s rules.
The .st score files can be read using the PhysioBank ATM and other software that reads PhysioBank-compatible annotation files. These files contain the same information as the .txt files; times are encoded as for other annotation files, and each annotation's aux string contains the associated event, duration, sleep stage, location, and (where available) body position.
Applications for this database
This database is intended to provide a useful number of carefully annotated examples of CAP in a representative variety of pathophysiologic contexts, for development and evaluation of automated CAP analyzers, as well as to support basic studies of the dynamics of CAP.
Several efforts have been made to develop a reliable automatic CAP-scoring algorithm [11]. Most of these methods rely on the extraction of spectral features from the EEG and on the application of machine-learning algorithms. Although all these methods achieve good results, none of them is yet applied to clinical practice since they either require some amount of clinician intervention or do not achieve a sufficient accuracy in the classification to support the clinical diagnosis. Some recordings from this database have been used for studies on features related to CAP phase A [12-16] and for training automatic CAP detection algorithms [17].
Acknowledgements
The CAP Sleep Database was contributed to PhysioNet by Professor Mario Giovanni Terzano, MD and Professor Liborio Parrino, MD. The team of sleep experts of the Sleep Disorders Center of the Ospedale Maggiore of Parma, Italy, who performed the scoring includes Andrea Grassi, MD, Fernando De Paolis, MD, Giulia Milioli, MD, Silvia Riccardi, MD, Nicoletta Azzi, BSc, and Valentina Rosso, BSc. The BIOSIP group at the Bioengineering Department of Politecnico di Milano, Italy contributed to the organization of the database and implemented the Matlab scripts.
PhysioNet also gratefully acknowledges the contributions of BIOSIP group member Sara Mariani, MSc, who coordinated the preparation of the database for public release and its documentation and related software as a PhysioNetWorks project during her visit to MIT.
Bibliography
- MG Terzano, D Mancia, MR Salati, G Costani, A Decembrino, L Parrino. The cyclic alternating pattern as a physiologic component of normal NREM sleep. Sleep 1985;8(2):137-145.
- L Parrino, R Ferri, O Bruni, M. G. Terzano. Cyclic alternating pattern (CAP): The marker of sleep instability. Sleep Med Rev 2012 Feb;16(1):27-45
- L Parrino, P Halasz, CA Tassinari, MG Terzano.C CAP, epilepsy and motor events during sleep: the unifying role of arousal. Sleep Med Rev 2006 Aug;10(4):267-285.
- MG Terzano, L Parrino, MC Spaggiari, V Palomba, M Rossi, A Smerieri. CAP variables and arousals as sleep electroencephalogram markers for primary insomnia. Clin Neurophysiol 2003 Sep;114(9):1715-1723.
- L Parrino, M Boselli, GP Buccino, MC Spaggiari, G Di Giovanni, MG Terzano. The cyclic alternating pattern plays a gate-control on periodic limb movements during non-rapid eye movement sleep. J Clin Neurophysiol 1996 Jul;13(4):314-323.
- W Hening. The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization. Clin Neurophysiol 2004 Sep;115(9):1965-1974.
- T Kato, JY Montplaisir, F Guitard, BJ Sessle, JP Lund, GJ Lavigne. Evidence that experimentally induced sleep bruxism is a consequence of transient arousal. J Dent Res 2003 Apr;82(4):284-288.
- M Zucconi, L Ferini-Strambi. NREM parasomnias: arousal disorders and differentiation from nocturnal frontal lobe epilepsy. Clin Neurophysiol 2000 Sep;111 Suppl 2:S129-S135.
- R Poryazova, E Werth, L Parrino, MG Terzano, CL Bassetti. Cyclic alternating pattern in narcolepsy patients and healthy controls after partial and total sleep deprivation. Clin Neurophysiol 2011 Sep;122(9):1788-1793.
- A Rechtscahffen, A. Kales. A manual of standardized terminology, techniques and scoring system for sleep stages in human subjects. National Institutes of Health, Neurological Information Network, Publication 204, 1968.
- MG Terzano, L Parrino, A Sherieri, R Chervin, S Chokroverty, C Guilleminault, M Hirshkowitz, M Mahowald, H Moldofsky, A Rosa, R Thomas, A Walters. Atlas, rules, and recording techniques for the scoring of cyclic alternating pattern (CAP) in human sleep. Sleep Med 2001 Nov;2(6):537-553.
- U Barcaro, E Bonanni, M Maestri, L Murri, L Parrino, MG Terzano. A general automatic method for the analysis of NREM sleep microstructure. Sleep Med 2004 Nov;5(6):567-576.
- R Largo, C Munteanu, A Rosa. CAP event detection by wavelets and GA tuning. Proc 2005 IEEE International Workshop on Intelligent Signal Processing 2005, pp. 44-48.
- R Ferri, O Bruni, S Miano, A Smerieri, K Spruyt, MG Terzano. Inter-rater reliability of sleep cyclic alternating pattern (CAP) scoring and validation of a new computer-assisted CAP scoring method. Clin Neurophysiol 2005 Mar;116(3):696-707.
- S Mariani, AM Bianchi, E Manfredini, V Rosso, MO Mendez, L Parrino, M Matteucci, A Grassi, S Cerutti, MG Terzano. Automatic detection of A phases of the cyclic alternating pattern during sleep. Proc IEEE Eng Med Biol Soc 2010;5085-5088.
- C Navona, U Barcaro, E Bonanni, F Di Martino, M Maestri, L Murri. An automatic method for the recognition and classification of the A-phases of the cyclic alternating pattern. Clin Neurophysiol 2002 Nov;113(11):1826-1831.
- S Mariani, E Manfredini, V Rosso, MO Mendez, AM Bianchi, M Matteucci, MG Terzano, S Cerutti, L Parrino. Characterization of A phases during the Cyclic Alternating Pattern of sleep. Clin Neurophysiol 2011 Oct;122(10):2016-2024.
Database files
Name Last modified Size Description
Parent Directory - gender-age.xlsx 2011-08-11 19:35 11K CAP.m 2011-08-12 13:39 1.7K ScoringReader.m 2011-08-19 17:30 4.2K CAP-sequence.jpg 2012-07-24 10:37 81K RECORDS 2012-07-24 18:49 1.0K list of record names brux1.edf.st 2012-07-25 14:50 12K brux2.edf.st 2012-07-25 14:50 47K ins1.edf.st 2012-07-25 14:50 40K ins2.edf.st 2012-07-25 14:50 64K ins3.edf.st 2012-07-25 14:50 36K ins4.edf.st 2012-07-25 14:50 34K ins5.edf.st 2012-07-25 14:50 68K ins6.edf.st 2012-07-25 14:50 43K ins7.edf.st 2012-07-25 14:50 61K ins8.edf.st 2012-07-25 14:50 39K ins9.edf.st 2012-07-25 14:50 42K n10.edf.st 2012-07-25 14:50 35K n11.edf.st 2012-07-25 14:50 44K n12.edf.st 2012-07-25 14:50 37K n13.edf.st 2012-07-25 14:50 45K n14.edf.st 2012-07-25 14:50 43K n1.edf.st 2012-07-25 14:50 52K n15.edf.st 2012-07-25 14:50 42K n16.edf.st 2012-07-25 14:50 43K n2.edf.st 2012-07-25 14:50 42K n3.edf.st 2012-07-25 14:50 42K n4.edf.st 2012-07-25 14:50 51K n5.edf.st 2012-07-25 14:50 49K n6.edf.st 2012-07-25 14:50 45K n7.edf.st 2012-07-25 14:50 42K n8.edf.st 2012-07-25 14:50 49K n9.edf.st 2012-07-25 14:50 39K narco1.edf.st 2012-07-25 14:50 41K narco2.edf.st 2012-07-25 14:50 12K narco3.edf.st 2012-07-25 14:50 64K narco4.edf.st 2012-07-25 14:50 48K narco5.edf.st 2012-07-25 14:50 32K nfle10.edf.st 2012-07-25 14:50 46K nfle11.edf.st 2012-07-25 14:50 49K nfle12.edf.st 2012-07-25 14:50 51K nfle13.edf.st 2012-07-25 14:50 59K nfle14.edf.st 2012-07-25 14:50 44K nfle15.edf.st 2012-07-25 14:50 50K nfle16.edf.st 2012-07-25 14:50 52K nfle1.edf.st 2012-07-25 14:50 49K nfle17.edf.st 2012-07-25 14:50 47K nfle18.edf.st 2012-07-25 14:50 52K nfle19.edf.st 2012-07-25 14:50 49K nfle2.edf.st 2012-07-25 14:50 48K nfle20.edf.st 2012-07-25 14:50 45K nfle21.edf.st 2012-07-25 14:50 64K nfle22.edf.st 2012-07-25 14:50 54K nfle23.edf.st 2012-07-25 14:50 47K nfle24.edf.st 2012-07-25 14:50 48K nfle25.edf.st 2012-07-25 14:50 50K nfle26.edf.st 2012-07-25 14:50 44K nfle27.edf.st 2012-07-25 14:50 34K nfle28.edf.st 2012-07-25 14:50 51K nfle29.edf.st 2012-07-25 14:50 48K nfle30.edf.st 2012-07-25 14:50 46K nfle31.edf.st 2012-07-25 14:50 40K nfle32.edf.st 2012-07-25 14:50 52K nfle33.edf.st 2012-07-25 14:50 51K nfle34.edf.st 2012-07-25 14:50 47K nfle35.edf.st 2012-07-25 14:50 40K nfle36.edf.st 2012-07-25 14:50 47K nfle37.edf.st 2012-07-25 14:50 46K nfle38.edf.st 2012-07-25 14:50 49K nfle3.edf.st 2012-07-25 14:50 50K nfle39.edf.st 2012-07-25 14:50 46K nfle4.edf.st 2012-07-25 14:50 53K nfle40.edf.st 2012-07-25 14:50 58K nfle5.edf.st 2012-07-25 14:50 52K nfle6.edf.st 2012-07-25 14:50 35K nfle7.edf.st 2012-07-25 14:50 63K nfle8.edf.st 2012-07-25 14:50 45K nfle9.edf.st 2012-07-25 14:50 54K plm1.edf.st 2012-07-25 14:50 55K plm10.edf.st 2012-07-25 14:50 46K plm2.edf.st 2012-07-25 14:50 40K plm3.edf.st 2012-07-25 14:50 49K plm4.edf.st 2012-07-25 14:50 41K plm5.edf.st 2012-07-25 14:50 39K plm6.edf.st 2012-07-25 14:50 33K plm7.edf.st 2012-07-25 14:50 44K plm8.edf.st 2012-07-25 14:50 37K plm9.edf.st 2012-07-25 14:50 42K rbd10.edf.st 2012-07-25 14:50 34K rbd11.edf.st 2012-07-25 14:50 33K rbd12.edf.st 2012-07-25 14:50 45K rbd13.edf.st 2012-07-25 14:50 57K rbd1.edf.st 2012-07-25 14:50 29K rbd14.edf.st 2012-07-25 14:50 49K rbd15.edf.st 2012-07-25 14:50 39K rbd16.edf.st 2012-07-25 14:50 48K rbd17.edf.st 2012-07-25 14:50 50K rbd18.edf.st 2012-07-25 14:50 40K rbd19.edf.st 2012-07-25 14:50 46K rbd2.edf.st 2012-07-25 14:50 60K rbd20.edf.st 2012-07-25 14:50 35K rbd21.edf.st 2012-07-25 14:50 53K rbd22.edf.st 2012-07-25 14:50 48K rbd3.edf.st 2012-07-25 14:50 56K rbd4.edf.st 2012-07-25 14:50 57K rbd5.edf.st 2012-07-25 14:50 54K rbd6.edf.st 2012-07-25 14:50 30K rbd7.edf.st 2012-07-25 14:50 44K rbd8.edf.st 2012-07-25 14:50 52K rbd9.edf.st 2012-07-25 14:50 45K sdb1.edf.st 2012-07-25 14:50 32K sdb2.edf.st 2012-07-25 14:50 48K sdb3.edf.st 2012-07-25 14:50 37K sdb4.edf.st 2012-07-25 14:50 59K ANNOTATORS 2012-07-25 14:56 43 list of annotators DOI 2015-09-21 13:00 20 sdb4.edf 2018-11-09 14:55 206M brux1.edf 2018-11-09 14:56 221M brux2.edf 2018-11-09 14:56 252M ins1.edf 2018-11-09 14:57 253M ins2.edf 2018-11-09 14:58 466M ins3.edf 2018-11-09 14:58 166M ins4.edf 2018-11-09 14:58 270M ins5.edf 2018-11-09 14:59 378M ins6.edf 2018-11-09 15:00 448M ins7.edf 2018-11-09 15:00 326M ins8.edf 2018-11-09 15:01 418M ins9.edf 2018-11-09 15:02 520M n1.edf 2018-11-09 15:02 473M n2.edf 2018-11-09 15:03 356M n3.edf 2018-11-09 15:04 525M n5.edf 2018-11-09 15:05 499M n6.edf 2018-11-09 15:05 62M n7.edf 2018-11-09 15:05 58M n9.edf 2018-11-09 15:06 62M n10.edf 2018-11-09 15:06 452M n11.edf 2018-11-09 15:07 494M n12.edf 2018-11-09 15:07 51M n13.edf 2018-11-09 15:08 118M n14.edf 2018-11-09 15:08 124M n16.edf 2018-11-09 15:08 29M narco1.edf 2018-11-09 15:09 318M narco2.edf 2018-11-09 15:09 257M narco3.edf 2018-11-09 15:10 416M narco4.edf 2018-11-09 15:11 518M narco5.edf 2018-11-09 15:11 191M nfle1.edf 2018-11-09 15:12 510M nfle2.edf 2018-11-09 15:12 491M nfle3.edf 2018-11-09 15:13 572M nfle4.edf 2018-11-09 15:14 551M nfle5.edf 2018-11-09 15:15 518M nfle6.edf 2018-11-09 15:15 153M nfle7.edf 2018-11-09 15:16 534M nfle8.edf 2018-11-09 15:17 232M nfle9.edf 2018-11-09 15:18 601M nfle10.edf 2018-11-09 15:18 158M nfle11.edf 2018-11-09 15:18 165M nfle12.edf 2018-11-09 15:19 547M nfle13.edf 2018-11-09 15:20 514M nfle14.edf 2018-11-09 15:21 482M nfle15.edf 2018-11-09 15:22 544M nfle16.edf 2018-11-09 15:22 525M nfle17.edf 2018-11-09 15:26 457M nfle18.edf 2018-11-09 15:27 542M nfle19.edf 2018-11-09 15:28 146M nfle20.edf 2018-11-09 15:28 183M nfle21.edf 2018-11-09 15:29 542M nfle22.edf 2018-11-09 15:30 531M nfle23.edf 2018-11-09 15:30 169M nfle24.edf 2018-11-09 15:31 482M nfle25.edf 2018-11-09 15:31 226M nfle26.edf 2018-11-09 15:31 157M nfle27.edf 2018-11-09 15:32 556M nfle28.edf 2018-11-09 15:33 567M nfle29.edf 2018-11-09 15:34 477M nfle30.edf 2018-11-09 15:35 545M nfle31.edf 2018-11-09 15:35 178M nfle32.edf 2018-11-09 15:36 479M nfle33.edf 2018-11-09 15:37 739M nfle34.edf 2018-11-09 15:38 526M nfle35.edf 2018-11-09 15:39 471M nfle36.edf 2018-11-09 15:40 520M nfle37.edf 2018-11-09 15:41 480M nfle38.edf 2018-11-09 15:41 529M nfle39.edf 2018-11-09 15:42 471M nfle40.edf 2018-11-09 15:43 563M plm1.edf 2018-11-09 15:44 276M plm2.edf 2018-11-09 15:45 357M plm3.edf 2018-11-09 15:45 382M plm4.edf 2018-11-09 15:46 326M plm5.edf 2018-11-09 15:46 428M plm6.edf 2018-11-09 15:47 500M plm7.edf 2018-11-09 15:48 293M plm8.edf 2018-11-09 15:48 232M plm9.edf 2018-11-09 15:49 491M plm10.edf 2018-11-09 15:49 360M rbd1.edf 2018-11-09 15:50 303M rbd2.edf 2018-11-09 15:51 542M rbd3.edf 2018-11-09 15:52 572M rbd4.edf 2018-11-09 15:53 523M rbd5.edf 2018-11-09 15:54 484M rbd6.edf 2018-11-09 15:54 527M rbd7.edf 2018-11-09 15:55 444M rbd8.edf 2018-11-09 15:56 449M rbd9.edf 2018-11-09 15:57 485M rbd10.edf 2018-11-09 15:57 358M rbd11.edf 2018-11-09 15:58 358M rbd12.edf 2018-11-09 15:59 456M rbd13.edf 2018-11-09 15:59 489M rbd14.edf 2018-11-09 16:00 339M rbd15.edf 2018-11-09 16:01 485M rbd16.edf 2018-11-09 16:02 471M rbd17.edf 2018-11-09 16:02 367M rbd18.edf 2018-11-09 16:03 516M rbd19.edf 2018-11-09 16:04 522M rbd20.edf 2018-11-09 16:04 297M rbd21.edf 2018-11-09 16:05 460M rbd22.edf 2018-11-09 16:06 484M sdb1.edf 2018-11-09 16:06 139M sdb2.edf 2018-11-09 16:06 143M sdb3.edf 2018-11-09 16:07 308M n15.edf 2018-11-14 16:39 124M n4.edf 2018-11-14 16:40 123M n8.edf 2018-11-14 16:40 88M brux1.txt 2018-11-16 13:51 72K brux2.txt 2018-11-16 13:51 74K ins1.txt 2018-11-16 13:51 42K ins2.txt 2018-11-16 13:51 65K ins3.txt 2018-11-16 13:51 38K ins4.txt 2018-11-16 13:51 35K ins5.txt 2018-11-16 13:51 70K ins6.txt 2018-11-16 13:51 60K ins7.txt 2018-11-16 13:51 63K ins8.txt 2018-11-16 13:51 61K ins9.txt 2018-11-16 13:51 65K n1.txt 2018-11-16 13:51 82K n10.txt 2018-11-16 13:51 55K n11.txt 2018-11-16 13:51 70K n12.txt 2018-11-16 13:51 60K n13.txt 2018-11-16 13:51 71K n14.txt 2018-11-16 13:51 68K n15.txt 2018-11-16 13:51 69K n16.txt 2018-11-16 13:51 73K n2.txt 2018-11-16 13:51 44K n3.txt 2018-11-16 13:51 44K n4.txt 2018-11-16 13:51 53K n5.txt 2018-11-16 13:51 77K n6.txt 2018-11-16 13:51 47K n7.txt 2018-11-16 13:51 68K n8.txt 2018-11-16 13:51 51K n9.txt 2018-11-16 13:51 63K narco1.txt 2018-11-16 13:51 43K narco2.txt 2018-11-16 13:51 65K narco3.txt 2018-11-16 13:51 94K narco4.txt 2018-11-16 13:51 75K narco5.txt 2018-11-16 13:51 45K nfle1.txt 2018-11-16 13:51 77K nfle10.txt 2018-11-16 13:51 72K nfle11.txt 2018-11-16 13:51 78K nfle12.txt 2018-11-16 13:51 53K nfle13.txt 2018-11-16 13:51 93K nfle14.txt 2018-11-16 13:51 69K nfle15.txt 2018-11-16 13:51 80K nfle16.txt 2018-11-16 13:51 81K nfle17.txt 2018-11-16 13:51 73K nfle18.txt 2018-11-16 13:51 81K nfle19.txt 2018-11-16 13:51 77K nfle2.txt 2018-11-16 13:51 51K nfle20.txt 2018-11-16 13:51 72K nfle21.txt 2018-11-16 13:51 67K nfle22.txt 2018-11-16 13:51 56K nfle23.txt 2018-11-16 13:51 75K nfle24.txt 2018-11-16 13:51 76K nfle25.txt 2018-11-16 13:51 80K nfle26.txt 2018-11-16 13:51 68K nfle27.txt 2018-11-16 13:51 59K nfle28.txt 2018-11-16 13:51 80K nfle29.txt 2018-11-16 13:51 50K nfle3.txt 2018-11-16 13:51 78K nfle30.txt 2018-11-16 13:51 72K nfle31.txt 2018-11-16 13:51 64K nfle32.txt 2018-11-16 13:51 54K nfle33.txt 2018-11-16 13:51 79K nfle34.txt 2018-11-16 13:51 74K nfle35.txt 2018-11-16 13:51 42K nfle36.txt 2018-11-16 13:51 73K nfle37.txt 2018-11-16 13:51 74K nfle38.txt 2018-11-16 13:51 77K nfle39.txt 2018-11-16 13:51 72K nfle4.txt 2018-11-16 13:52 84K nfle40.txt 2018-11-16 13:52 92K nfle5.txt 2018-11-16 13:52 54K nfle6.txt 2018-11-16 13:52 55K nfle7.txt 2018-11-16 13:52 100K nfle8.txt 2018-11-16 13:52 72K nfle9.txt 2018-11-16 13:52 56K plm1.txt 2018-11-16 13:52 87K plm10.txt 2018-11-16 13:52 72K plm2.txt 2018-11-16 13:52 63K plm3.txt 2018-11-16 13:52 78K plm4.txt 2018-11-16 13:52 43K plm5.txt 2018-11-16 13:52 41K plm6.txt 2018-11-16 13:52 51K plm7.txt 2018-11-16 13:52 69K plm8.txt 2018-11-16 13:52 39K plm9.txt 2018-11-16 13:52 66K rbd1.txt 2018-11-16 13:52 46K rbd10.txt 2018-11-16 13:52 52K rbd11.txt 2018-11-16 13:52 35K 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