Follow the following steps to apply this software to physionet 2010 challenge data: 1. Create two folders, "physionetdata" and "code", in the same level. 2. Place physionet data into the folder "physionetdata". Separate data from each set to subfolders, such as "set-a", "set-b", and "set-c," respectively. 3. Place AFF_fill.m into the folder "code." 4. Run the software in matlab. 5. The code can be run in parallel in a cluster to speed up computation. Address comments and questions to Xiaopeng Zhao Nonlinear Biodynamics Laboratory Department of Biomedical Engineering University of Tennessee Knoxville, TN 37996