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The Cyclic Alternating Pattern (CAP) of EEG activity during sleep
The Cyclic Alternating Pattern (CAP) is a periodic EEG activity occurring during NREM sleep. It is characterized by cyclic sequences of cerebral activation (phase A) followed by periods of deactivation (phase B) which separate two successive phase A periods with an interval <1 min. A phase A period and the following phase B period define a CAP cycle, and at least two CAP cycles are required to form a CAP sequence.
An example of cyclic alternating pattern (CAP) in sleep stage 2. A CAP cycle is defined as a phase A period followed by a phase B period lasting a minute or less. Two or more adjacent CAP cycles define a CAP sequence.
Phase A periods are subdivided into three subtypes:
- Subtype A1: synchronized events with low impact on autonomic and somatomotor activities;
- Subtype A2: mixed synchronized–desynchronized EEG events with an intermediate influence on the autonomic and somatomotor activities; and
- Subtype A3: predominantly desynchronized EEG events with heavy effects on the autonomic and somatomotor activities.
A detailed description and definition of CAP is reported in [1]. For a complete review of the history and significance of CAP, see [2].
Despite being a physiological phenomenon, CAP is also a marker of sleep instability and can be correlated with several sleep-related pathologies. In fact, on one hand CAP can reflect a reaction of the sleeping brain to any endogenous or exogenous disturbance; on the other hand, the A phase of CAP has been interpreted as a kind of gate through which pathological events more easily occur [3]. Increased amounts of CAP are often observed in sleep-disordered breathing (SDB), as well as in insomnia [4], sleep movement disorders (periodic leg movements, or PLM [5], restless leg syndrome (RLS) [6], parasomnias like REM behavior disorder (RBD), and epileptic diseases such as nocturnal frontal lobe epilepsy (NFLE) [7]. Pathological amounts of CAP can also be found in hypersomnias of central origin such as narcolepsy [8].
The ratio between NREM CAP sleep and total NREM sleep (CAP-rate), and the different distributions of CAP A phases with respect to sleep stages can be measured in sleep centers to characterize such pathologies. These indexes can be valuable as measures of sleep quality, but the time needed to determine them has been an obstacle to their adoption in routine clinical practice, since visual scoring of CAP phases A for an entire night of sleep recording requires expertise and lengthy, attentive analysis. The development of software capable of increasingly accurate and efficient automated analysis of CAP is beginning to result in wider clinical use of CAP indexes for diagnosis of sleep pathologies and assessment of the efficacy of therapeutic interventions.
The CAP Sleep Database
The CAP Sleep Database is a collection of 108 polysomnographic recordings registered at the Sleep Disorders Center of the Ospedale Maggiore of Parma, Italy. The waveforms (contained in the .edf files of the database) include at least 3 EEG channels (F3 or F4, C3 or C4 and O1 or O2, referred to A1 or A2), EOG (2 channels), EMG of the submentalis muscle, bilateral anterior tibial EMG, respiration signals (airflow, abdominal and thoracic effort and SaO2) and EKG. Additional traces include EEG bipolar traces, according to the 10-20 international system (Fp1-F3, F3-C3, C3-P3, P3-O1 and/or Fp2-F4, F4-C4, C4-P4, P4-O2).
The 16 healthy subjects included in the study did not present any neurological disorders and were free of drugs affecting the central nervous system. The 92 pathological recordings include 40 recordings of patients diagnosed with NFLE, 22 affected by RBD, 10 with PLM, 9 insomniac, 5 narcoleptic, 4 affected by SDB and 2 by bruxism. The age and gender of the subjects are reported in a spreadsheet (gender-age.xlsx).
The recordings are named according to the subjects' pathology:
n1-n16 | No pathology (controls) |
brux1-brux2 | Bruxism |
ins1-ins9 | Insomnia |
narco1-narco5 | Narcolepsy |
nfle1-nfle40 | Nocturnal frontal lobe epilepsy |
plm1-plm10 | Periodic leg movements |
rbd1-rbd22 | REM behavior disorder |
sdb1-sdb4 | Sleep-disordered breathing |
Annotations
Expert neurologists trained at the Sleep Center provided the scoring of the sleep macrostructure, according to the Rechtschaffen & Kales rules [9], while the CAP was detected in agreement with Terzano’s reference atlas of rules [10]. All the signals were visualized and the scorings were performed using REMlogic™ software (Embla).
The scores for each recording are provided as .txt files in REMlogic report format, and also as .st files in PhysioBank-compatible format. The .txt score files have the following fields:
- Sleep stage (W=wake, S1-S4=sleep stages, R=REM, MT=body movements)
- Body position (Left, Right, Prone, or Supine; not recorded in some subjects)
- Time of day [hh:mm:ss]
- Event (either a sleep stage (SLEEP-S0..S4, REM, MT), or a phase A of CAP)
- Duration (in seconds)
- Location (the signal(s) in which the event can be observed)
A Matlab script is provided for reading the .txt score files easily. By launching ScoringReader.m, an array containing the scoring of the macrostructure, and three arrays containing the starting time of the CAP A phases, their duration and their subtype, are generated. The hypnogram is reported as 0 for wake, 1 to 4 for the sleep stages, according to R&K rules, and 5 for REM. The Matlab function CAP.m computes, starting from these variables, the CAP time and CAP rate according to Terzano’s rules.
The .st score files can be read using the PhysioBank ATM and other software that reads PhysioBank-compatible annotation files. These files contain the same information as the .txt files; times are encoded as for other annotation files, and each annotation's aux string contains the associated event, duration, sleep stage, location, and (where available) body position.
Applications for this database
This database is intended to provide a useful number of carefully annotated examples of CAP in a representative variety of pathophysiologic contexts, for development and evaluation of automated CAP analyzers, as well as to support basic studies of the dynamics of CAP.
Several efforts have been made to develop a reliable automatic CAP-scoring algorithm [11]. Most of these methods rely on the extraction of spectral features from the EEG and on the application of machine-learning algorithms. Although all these methods achieve good results, none of them is yet applied to clinical practice since they either require some amount of clinician intervention or do not achieve a sufficient accuracy in the classification to support the clinical diagnosis. Some recordings from this database have been used for studies on features related to CAP phase A [12-16] and for training automatic CAP detection algorithms [17].
Acknowledgements
The CAP Sleep Database was contributed to PhysioNet by Professor Mario Giovanni Terzano, MD and Professor Liborio Parrino, MD. The team of sleep experts of the Sleep Disorders Center of the Ospedale Maggiore of Parma, Italy, who performed the scoring includes Andrea Grassi, MD, Fernando De Paolis, MD, Giulia Milioli, MD, Silvia Riccardi, MD, Nicoletta Azzi, BSc, and Valentina Rosso, BSc. The BIOSIP group at the Bioengineering Department of Politecnico di Milano, Italy contributed to the organization of the database and implemented the Matlab scripts.
PhysioNet also gratefully acknowledges the contributions of BIOSIP group member Sara Mariani, MSc, who coordinated the preparation of the database for public release and its documentation and related software as a PhysioNetWorks project during her visit to MIT.
Bibliography
- MG Terzano, D Mancia, MR Salati, G Costani, A Decembrino, L Parrino. The cyclic alternating pattern as a physiologic component of normal NREM sleep. Sleep 1985;8(2):137-145.
- L Parrino, R Ferri, O Bruni, M. G. Terzano. Cyclic alternating pattern (CAP): The marker of sleep instability. Sleep Med Rev 2012 Feb;16(1):27-45
- L Parrino, P Halasz, CA Tassinari, MG Terzano.C CAP, epilepsy and motor events during sleep: the unifying role of arousal. Sleep Med Rev 2006 Aug;10(4):267-285.
- MG Terzano, L Parrino, MC Spaggiari, V Palomba, M Rossi, A Smerieri. CAP variables and arousals as sleep electroencephalogram markers for primary insomnia. Clin Neurophysiol 2003 Sep;114(9):1715-1723.
- L Parrino, M Boselli, GP Buccino, MC Spaggiari, G Di Giovanni, MG Terzano. The cyclic alternating pattern plays a gate-control on periodic limb movements during non-rapid eye movement sleep. J Clin Neurophysiol 1996 Jul;13(4):314-323.
- W Hening. The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization. Clin Neurophysiol 2004 Sep;115(9):1965-1974.
- T Kato, JY Montplaisir, F Guitard, BJ Sessle, JP Lund, GJ Lavigne. Evidence that experimentally induced sleep bruxism is a consequence of transient arousal. J Dent Res 2003 Apr;82(4):284-288.
- M Zucconi, L Ferini-Strambi. NREM parasomnias: arousal disorders and differentiation from nocturnal frontal lobe epilepsy. Clin Neurophysiol 2000 Sep;111 Suppl 2:S129-S135.
- R Poryazova, E Werth, L Parrino, MG Terzano, CL Bassetti. Cyclic alternating pattern in narcolepsy patients and healthy controls after partial and total sleep deprivation. Clin Neurophysiol 2011 Sep;122(9):1788-1793.
- A Rechtscahffen, A. Kales. A manual of standardized terminology, techniques and scoring system for sleep stages in human subjects. National Institutes of Health, Neurological Information Network, Publication 204, 1968.
- MG Terzano, L Parrino, A Sherieri, R Chervin, S Chokroverty, C Guilleminault, M Hirshkowitz, M Mahowald, H Moldofsky, A Rosa, R Thomas, A Walters. Atlas, rules, and recording techniques for the scoring of cyclic alternating pattern (CAP) in human sleep. Sleep Med 2001 Nov;2(6):537-553.
- U Barcaro, E Bonanni, M Maestri, L Murri, L Parrino, MG Terzano. A general automatic method for the analysis of NREM sleep microstructure. Sleep Med 2004 Nov;5(6):567-576.
- R Largo, C Munteanu, A Rosa. CAP event detection by wavelets and GA tuning. Proc 2005 IEEE International Workshop on Intelligent Signal Processing 2005, pp. 44-48.
- R Ferri, O Bruni, S Miano, A Smerieri, K Spruyt, MG Terzano. Inter-rater reliability of sleep cyclic alternating pattern (CAP) scoring and validation of a new computer-assisted CAP scoring method. Clin Neurophysiol 2005 Mar;116(3):696-707.
- S Mariani, AM Bianchi, E Manfredini, V Rosso, MO Mendez, L Parrino, M Matteucci, A Grassi, S Cerutti, MG Terzano. Automatic detection of A phases of the cyclic alternating pattern during sleep. Proc IEEE Eng Med Biol Soc 2010;5085-5088.
- C Navona, U Barcaro, E Bonanni, F Di Martino, M Maestri, L Murri. An automatic method for the recognition and classification of the A-phases of the cyclic alternating pattern. Clin Neurophysiol 2002 Nov;113(11):1826-1831.
- S Mariani, E Manfredini, V Rosso, MO Mendez, AM Bianchi, M Matteucci, MG Terzano, S Cerutti, L Parrino. Characterization of A phases during the Cyclic Alternating Pattern of sleep. Clin Neurophysiol 2011 Oct;122(10):2016-2024.
Database files
Name Last modified Size Description
Parent Directory - DOI 2015-09-21 13:00 20 ANNOTATORS 2012-07-25 14:56 43 list of annotators RECORDS 2012-07-24 18:49 1.0K list of record names CAP.m 2011-08-12 13:39 1.7K ScoringReader.m 2011-08-19 17:30 4.2K gender-age.xlsx 2011-08-11 19:35 11K brux1.edf.st 2012-07-25 14:50 12K narco2.edf.st 2012-07-25 14:50 12K MD5SUMS 2018-11-16 14:10 14K SHA1SUMS 2018-11-16 14:10 17K SHA256SUMS 2018-11-16 14:10 25K rbd1.edf.st 2012-07-25 14:50 29K rbd6.edf.st 2012-07-25 14:50 30K rbd6.txt 2018-11-16 13:52 31K narco5.edf.st 2012-07-25 14:50 32K sdb1.edf.st 2012-07-25 14:50 32K plm6.edf.st 2012-07-25 14:50 33K rbd11.edf.st 2012-07-25 14:50 33K rbd10.edf.st 2012-07-25 14:50 34K ins4.edf.st 2012-07-25 14:50 34K nfle27.edf.st 2012-07-25 14:50 34K rbd11.txt 2018-11-16 13:52 35K n10.edf.st 2012-07-25 14:50 35K nfle6.edf.st 2012-07-25 14:50 35K rbd20.edf.st 2012-07-25 14:50 35K ins4.txt 2018-11-16 13:51 35K ins3.edf.st 2012-07-25 14:50 36K plm8.edf.st 2012-07-25 14:50 37K sdb3.edf.st 2012-07-25 14:50 37K n12.edf.st 2012-07-25 14:50 37K ins3.txt 2018-11-16 13:51 38K sdb3.txt 2018-11-16 13:52 39K rbd15.edf.st 2012-07-25 14:50 39K plm8.txt 2018-11-16 13:52 39K n9.edf.st 2012-07-25 14:50 39K ins8.edf.st 2012-07-25 14:50 39K plm5.edf.st 2012-07-25 14:50 39K nfle31.edf.st 2012-07-25 14:50 40K ins1.edf.st 2012-07-25 14:50 40K nfle35.edf.st 2012-07-25 14:50 40K plm2.edf.st 2012-07-25 14:50 40K rbd18.edf.st 2012-07-25 14:50 40K plm4.edf.st 2012-07-25 14:50 41K plm5.txt 2018-11-16 13:52 41K narco1.edf.st 2012-07-25 14:50 41K ins9.edf.st 2012-07-25 14:50 42K ins1.txt 2018-11-16 13:51 42K nfle35.txt 2018-11-16 13:51 42K n7.edf.st 2012-07-25 14:50 42K n15.edf.st 2012-07-25 14:50 42K plm9.edf.st 2012-07-25 14:50 42K n3.edf.st 2012-07-25 14:50 42K n2.edf.st 2012-07-25 14:50 42K plm4.txt 2018-11-16 13:52 43K ins6.edf.st 2012-07-25 14:50 43K narco1.txt 2018-11-16 13:51 43K n16.edf.st 2012-07-25 14:50 43K n14.edf.st 2012-07-25 14:50 43K nfle26.edf.st 2012-07-25 14:50 44K plm7.edf.st 2012-07-25 14:50 44K n3.txt 2018-11-16 13:51 44K nfle14.edf.st 2012-07-25 14:50 44K n2.txt 2018-11-16 13:51 44K rbd7.edf.st 2012-07-25 14:50 44K n11.edf.st 2012-07-25 14:50 44K n6.edf.st 2012-07-25 14:50 45K rbd12.edf.st 2012-07-25 14:50 45K n13.edf.st 2012-07-25 14:50 45K rbd9.edf.st 2012-07-25 14:50 45K nfle8.edf.st 2012-07-25 14:50 45K narco5.txt 2018-11-16 13:51 45K nfle20.edf.st 2012-07-25 14:50 45K nfle10.edf.st 2012-07-25 14:50 46K nfle39.edf.st 2012-07-25 14:50 46K nfle30.edf.st 2012-07-25 14:50 46K rbd1.txt 2018-11-16 13:52 46K plm10.edf.st 2012-07-25 14:50 46K nfle37.edf.st 2012-07-25 14:50 46K rbd19.edf.st 2012-07-25 14:50 46K nfle36.edf.st 2012-07-25 14:50 47K rbd12.txt 2018-11-16 13:52 47K nfle17.edf.st 2012-07-25 14:50 47K nfle34.edf.st 2012-07-25 14:50 47K brux2.edf.st 2012-07-25 14:50 47K n6.txt 2018-11-16 13:51 47K nfle23.edf.st 2012-07-25 14:50 47K narco4.edf.st 2012-07-25 14:50 48K rbd22.edf.st 2012-07-25 14:50 48K nfle24.edf.st 2012-07-25 14:50 48K nfle29.edf.st 2012-07-25 14:50 48K sdb2.edf.st 2012-07-25 14:50 48K nfle2.edf.st 2012-07-25 14:50 48K rbd16.edf.st 2012-07-25 14:50 48K rbd14.edf.st 2012-07-25 14:50 49K nfle19.edf.st 2012-07-25 14:50 49K nfle11.edf.st 2012-07-25 14:50 49K n5.edf.st 2012-07-25 14:50 49K nfle38.edf.st 2012-07-25 14:50 49K nfle1.edf.st 2012-07-25 14:50 49K plm3.edf.st 2012-07-25 14:50 49K n8.edf.st 2012-07-25 14:50 49K nfle3.edf.st 2012-07-25 14:50 50K nfle29.txt 2018-11-16 13:51 50K nfle25.edf.st 2012-07-25 14:50 50K rbd17.edf.st 2012-07-25 14:50 50K nfle15.edf.st 2012-07-25 14:50 50K nfle2.txt 2018-11-16 13:51 51K sdb1.txt 2018-11-16 13:52 51K n4.edf.st 2012-07-25 14:50 51K nfle28.edf.st 2012-07-25 14:50 51K nfle12.edf.st 2012-07-25 14:50 51K nfle33.edf.st 2012-07-25 14:50 51K n8.txt 2018-11-16 13:51 51K plm6.txt 2018-11-16 13:52 51K nfle18.edf.st 2012-07-25 14:50 52K rbd8.edf.st 2012-07-25 14:50 52K nfle16.edf.st 2012-07-25 14:50 52K n1.edf.st 2012-07-25 14:50 52K nfle32.edf.st 2012-07-25 14:50 52K nfle5.edf.st 2012-07-25 14:50 52K rbd10.txt 2018-11-16 13:52 52K rbd21.edf.st 2012-07-25 14:50 53K nfle12.txt 2018-11-16 13:51 53K n4.txt 2018-11-16 13:51 53K nfle4.edf.st 2012-07-25 14:50 53K nfle22.edf.st 2012-07-25 14:50 54K nfle9.edf.st 2012-07-25 14:50 54K rbd5.edf.st 2012-07-25 14:50 54K nfle32.txt 2018-11-16 13:51 54K nfle5.txt 2018-11-16 13:52 54K rbd20.txt 2018-11-16 13:52 55K n10.txt 2018-11-16 13:51 55K rbd21.txt 2018-11-16 13:52 55K nfle6.txt 2018-11-16 13:52 55K plm1.edf.st 2012-07-25 14:50 55K rbd3.edf.st 2012-07-25 14:50 56K rbd5.txt 2018-11-16 13:52 56K nfle9.txt 2018-11-16 13:52 56K nfle22.txt 2018-11-16 13:51 56K rbd13.edf.st 2012-07-25 14:50 57K rbd4.edf.st 2012-07-25 14:50 57K rbd3.txt 2018-11-16 13:52 58K nfle40.edf.st 2012-07-25 14:50 58K rbd4.txt 2018-11-16 13:52 59K rbd13.txt 2018-11-16 13:52 59K nfle13.edf.st 2012-07-25 14:50 59K nfle27.txt 2018-11-16 13:51 59K sdb4.edf.st 2012-07-25 14:50 59K n12.txt 2018-11-16 13:51 60K ins6.txt 2018-11-16 13:51 60K rbd2.edf.st 2012-07-25 14:50 60K rbd15.txt 2018-11-16 13:52 60K ins7.edf.st 2012-07-25 14:50 61K ins8.txt 2018-11-16 13:51 61K ins7.txt 2018-11-16 13:51 63K nfle7.edf.st 2012-07-25 14:50 63K n9.txt 2018-11-16 13:51 63K plm2.txt 2018-11-16 13:52 63K rbd18.txt 2018-11-16 13:52 64K ins2.edf.st 2012-07-25 14:50 64K nfle31.txt 2018-11-16 13:51 64K narco3.edf.st 2012-07-25 14:50 64K nfle21.edf.st 2012-07-25 14:50 64K narco2.txt 2018-11-16 13:51 65K ins9.txt 2018-11-16 13:51 65K ins2.txt 2018-11-16 13:51 65K plm9.txt 2018-11-16 13:52 66K nfle21.txt 2018-11-16 13:51 67K n14.txt 2018-11-16 13:51 68K nfle26.txt 2018-11-16 13:51 68K n7.txt 2018-11-16 13:51 68K ins5.edf.st 2012-07-25 14:50 68K plm7.txt 2018-11-16 13:52 69K rbd7.txt 2018-11-16 13:52 69K n15.txt 2018-11-16 13:51 69K nfle14.txt 2018-11-16 13:51 69K ins5.txt 2018-11-16 13:51 70K n11.txt 2018-11-16 13:51 70K rbd9.txt 2018-11-16 13:52 71K n13.txt 2018-11-16 13:51 71K nfle10.txt 2018-11-16 13:51 72K nfle39.txt 2018-11-16 13:51 72K nfle20.txt 2018-11-16 13:51 72K plm10.txt 2018-11-16 13:52 72K nfle8.txt 2018-11-16 13:52 72K brux1.txt 2018-11-16 13:51 72K nfle30.txt 2018-11-16 13:51 72K rbd19.txt 2018-11-16 13:52 73K n16.txt 2018-11-16 13:51 73K nfle17.txt 2018-11-16 13:51 73K nfle36.txt 2018-11-16 13:51 73K nfle37.txt 2018-11-16 13:51 74K nfle34.txt 2018-11-16 13:51 74K brux2.txt 2018-11-16 13:51 74K rbd22.txt 2018-11-16 13:52 75K narco4.txt 2018-11-16 13:51 75K nfle23.txt 2018-11-16 13:51 75K rbd14.txt 2018-11-16 13:52 76K nfle24.txt 2018-11-16 13:51 76K rbd16.txt 2018-11-16 13:52 76K sdb2.txt 2018-11-16 13:52 76K n5.txt 2018-11-16 13:51 77K nfle1.txt 2018-11-16 13:51 77K nfle38.txt 2018-11-16 13:51 77K nfle19.txt 2018-11-16 13:51 77K nfle11.txt 2018-11-16 13:51 78K nfle3.txt 2018-11-16 13:51 78K plm3.txt 2018-11-16 13:52 78K rbd17.txt 2018-11-16 13:52 78K nfle33.txt 2018-11-16 13:51 79K nfle25.txt 2018-11-16 13:51 80K nfle15.txt 2018-11-16 13:51 80K nfle28.txt 2018-11-16 13:51 80K CAP-sequence.jpg 2012-07-24 10:37 81K nfle18.txt 2018-11-16 13:51 81K nfle16.txt 2018-11-16 13:51 81K rbd8.txt 2018-11-16 13:52 82K n1.txt 2018-11-16 13:51 82K nfle4.txt 2018-11-16 13:52 84K plm1.txt 2018-11-16 13:52 87K nfle40.txt 2018-11-16 13:52 92K nfle13.txt 2018-11-16 13:51 93K narco3.txt 2018-11-16 13:51 94K rbd2.txt 2018-11-16 13:52 94K sdb4.txt 2018-11-16 13:52 95K nfle7.txt 2018-11-16 13:52 100K n16.edf 2018-11-09 15:08 29M n12.edf 2018-11-09 15:07 51M n7.edf 2018-11-09 15:05 58M n6.edf 2018-11-09 15:05 62M n9.edf 2018-11-09 15:06 62M n8.edf 2018-11-14 16:40 88M n13.edf 2018-11-09 15:08 118M n4.edf 2018-11-14 16:40 123M n14.edf 2018-11-09 15:08 124M n15.edf 2018-11-14 16:39 124M sdb1.edf 2018-11-09 16:06 139M sdb2.edf 2018-11-09 16:06 143M nfle19.edf 2018-11-09 15:28 146M nfle6.edf 2018-11-09 15:15 153M nfle26.edf 2018-11-09 15:31 157M nfle10.edf 2018-11-09 15:18 158M nfle11.edf 2018-11-09 15:18 165M ins3.edf 2018-11-09 14:58 166M nfle23.edf 2018-11-09 15:30 169M nfle31.edf 2018-11-09 15:35 178M nfle20.edf 2018-11-09 15:28 183M narco5.edf 2018-11-09 15:11 191M sdb4.edf 2018-11-09 14:55 206M brux1.edf 2018-11-09 14:56 221M nfle25.edf 2018-11-09 15:31 226M nfle8.edf 2018-11-09 15:17 232M plm8.edf 2018-11-09 15:48 232M brux2.edf 2018-11-09 14:56 252M ins1.edf 2018-11-09 14:57 253M narco2.edf 2018-11-09 15:09 257M ins4.edf 2018-11-09 14:58 270M plm1.edf 2018-11-09 15:44 276M plm7.edf 2018-11-09 15:48 293M rbd20.edf 2018-11-09 16:04 297M rbd1.edf 2018-11-09 15:50 303M sdb3.edf 2018-11-09 16:07 308M narco1.edf 2018-11-09 15:09 318M ins7.edf 2018-11-09 15:00 326M plm4.edf 2018-11-09 15:46 326M rbd14.edf 2018-11-09 16:00 339M n2.edf 2018-11-09 15:03 356M plm2.edf 2018-11-09 15:45 357M rbd10.edf 2018-11-09 15:57 358M rbd11.edf 2018-11-09 15:58 358M plm10.edf 2018-11-09 15:49 360M rbd17.edf 2018-11-09 16:02 367M ins5.edf 2018-11-09 14:59 378M plm3.edf 2018-11-09 15:45 382M narco3.edf 2018-11-09 15:10 416M ins8.edf 2018-11-09 15:01 418M plm5.edf 2018-11-09 15:46 428M rbd7.edf 2018-11-09 15:55 444M ins6.edf 2018-11-09 15:00 448M rbd8.edf 2018-11-09 15:56 449M n10.edf 2018-11-09 15:06 452M rbd12.edf 2018-11-09 15:59 456M nfle17.edf 2018-11-09 15:26 457M rbd21.edf 2018-11-09 16:05 460M ins2.edf 2018-11-09 14:58 466M rbd16.edf 2018-11-09 16:02 471M nfle35.edf 2018-11-09 15:39 471M nfle39.edf 2018-11-09 15:42 471M n1.edf 2018-11-09 15:02 473M nfle29.edf 2018-11-09 15:34 477M nfle32.edf 2018-11-09 15:36 479M nfle37.edf 2018-11-09 15:41 480M nfle14.edf 2018-11-09 15:21 482M nfle24.edf 2018-11-09 15:31 482M rbd22.edf 2018-11-09 16:06 484M rbd5.edf 2018-11-09 15:54 484M rbd15.edf 2018-11-09 16:01 485M rbd9.edf 2018-11-09 15:57 485M rbd13.edf 2018-11-09 15:59 489M nfle2.edf 2018-11-09 15:12 491M plm9.edf 2018-11-09 15:49 491M n11.edf 2018-11-09 15:07 494M n5.edf 2018-11-09 15:05 499M plm6.edf 2018-11-09 15:47 500M nfle1.edf 2018-11-09 15:12 510M nfle13.edf 2018-11-09 15:20 514M rbd18.edf 2018-11-09 16:03 516M nfle5.edf 2018-11-09 15:15 518M narco4.edf 2018-11-09 15:11 518M nfle36.edf 2018-11-09 15:40 520M ins9.edf 2018-11-09 15:02 520M rbd19.edf 2018-11-09 16:04 522M rbd4.edf 2018-11-09 15:53 523M nfle16.edf 2018-11-09 15:22 525M n3.edf 2018-11-09 15:04 525M nfle34.edf 2018-11-09 15:38 526M rbd6.edf 2018-11-09 15:54 527M nfle38.edf 2018-11-09 15:41 529M nfle22.edf 2018-11-09 15:30 531M nfle7.edf 2018-11-09 15:16 534M nfle21.edf 2018-11-09 15:29 542M rbd2.edf 2018-11-09 15:51 542M nfle18.edf 2018-11-09 15:27 542M nfle15.edf 2018-11-09 15:22 544M nfle30.edf 2018-11-09 15:35 545M nfle12.edf 2018-11-09 15:19 547M nfle4.edf 2018-11-09 15:14 551M nfle27.edf 2018-11-09 15:32 556M nfle40.edf 2018-11-09 15:43 563M nfle28.edf 2018-11-09 15:33 567M rbd3.edf 2018-11-09 15:52 572M nfle3.edf 2018-11-09 15:13 572M nfle9.edf 2018-11-09 15:18 601M nfle33.edf 2018-11-09 15:37 739M
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