Gait Dynamics in Neuro-Degenerative Disease Data Base

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Neuro-degenerative disease often affects gait and mobility. To understand better the pathophysiology of these diseases and to improve our ability to measure responses to therapeutic interventions, it may be helpful to quantify gait dynamics accurately. The records in this database are from patients with Parkinson's disease (n = 15), Huntington's disease (n = 20), or amyotrophic lateral sclerosis (n = 13). Records from 16 healthy control subjects are also included here.

The raw data were obtained using force-sensitive resistors, with the output roughly proportional to the force under the foot. Stride-to-stride measures of footfall contact times were derived from these signals, as illustrated below. (Click here for a PostScript version of this figure.)

Each of the 64 records is identified by the name of the subject group (hunt, park, als, or control) followed by an arbitrary ID number. The four files associated with each record have names beginning with the record name, and suffixes indicating the type and contents of the file:

Suffix	Contents
`.hea`	Header (text)
`.let`	Left foot signal (binary)
`.rit`	Right foot signal (binary)
`.ts`	Derived time series (text)

Within the time series (.ts) files, the contents are:

Column	Contents
1	Elapsed Time (sec)
2	Left Stride Interval (sec)
3	Right Stride Interval (sec)
4	Left Swing Interval (sec)
5	Right Swing Interval (sec)
6	Left Swing Interval (% of stride)
7	Right Swing Interval (% of stride)
8	Left Stance Interval (sec)
9	Right Stance Interval (sec)
10	Left Stance Interval (% of stride)
11	Right Stance Interval (% of stride)
12	Double Support Interval (sec)
13	Double Support Interval (% of stride)

Please note that these time series have not been filtered.

A separate file (subject-description.txt, a tab-delimited text file) includes clinical information for each subject, including age, gender, height, weight, walking speed, and a measure of disease severity or duration. For the subjects with Parkinson's disease, this is the Hohn and Yahr score (a higher score indicates more advanced disease). For the subjects with Huntington's disease, this is the total functional capacity measure (a lower score indicates more advanced functional impairment). For the subjects with amyotrophic lateral sclerosis, the number here is the time in months since the diagnosis of the disease. For the control subjects, an arbitrary 0 is used as a place holder.

Questions for study

We have done some initial analyses of these data sets. Much, however, is still unknown. For example: Are the dynamics of the sub-phases of the stride (e.g., stance and swing) identical to that of the stride itself? What is the effect of disease on gait asymmetry? Are stride dynamics nonlinear? Does this change with disease?

References

We have reported the association between disease and the dynamics of the stride time. For more information about our analyses of these data files, please see:

Hausdorff JM, Lertratanakul A, Cudkowicz ME, Peterson AL, Kaliton D, Goldberger AL. Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis. J Applied Physiology; 88:2045-2053, 2000.
Hausdorff JM, Mitchell SL, Firtion R, Peng CK, Cudkowicz ME, Wei JY, Goldberger AL. Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease. J Applied Physiology; 82:262-269, 1997.

Address for correspondence: jhausdor@caregroup.harvard.edu

 Name                    Last modified      Size  Description
 Parent Directory                             -   
 subject-description.txt 2000-11-07 12:08  2.3K  clinical information
 park9.ts                2000-11-07 12:56   19K  time series
 park9.rit               2012-11-17 15:06  132K  right foot signal
 park9.let               2012-11-17 15:06  132K  left foot signal
 park9.hea-              2000-11-07 12:56   56   header file
 park9.hea               2012-11-17 15:06  116   header file
 park8.ts                2000-11-07 12:56   17K  time series
 park8.rit               2012-11-17 15:06  132K  right foot signal
 park8.let               2012-11-17 15:06  132K  left foot signal
 park8.hea-              2000-11-07 12:56   56   header file
 park8.hea               2012-11-17 15:06  118   header file
 park7.ts                2000-11-07 12:56   19K  time series
 park7.rit               2012-11-17 15:06  132K  right foot signal
 park7.let               2012-11-17 15:06  132K  left foot signal
 park7.hea-              2000-11-07 12:56   59   header file
 park7.hea               2012-11-17 15:06  113   header file
 park6.ts                2000-11-07 12:55   23K  time series
 park6.rit               2012-11-17 15:06  132K  right foot signal
 park6.let               2012-11-17 15:06  132K  left foot signal
 park6.hea-              2000-11-07 12:55   56   header file
 park6.hea               2012-11-17 15:06  115   header file
 park5.ts                2000-11-07 12:55   23K  time series
 park5.rit               2012-11-17 15:06  132K  right foot signal
 park5.let               2012-11-17 15:06  132K  left foot signal
 park5.hea-              2000-11-07 12:55   56   header file
 park5.hea               2012-11-17 15:06  115   header file
 park4.ts                2000-11-07 12:55   19K  time series
 park4.rit               2012-11-17 15:06  132K  right foot signal
 park4.let               2012-11-17 15:06  132K  left foot signal
 park4.hea-              2000-11-07 12:55   56   header file
 park4.hea               2012-11-17 15:06  115   header file
 park3.ts                2000-11-07 12:55   20K  time series
 park3.rit               2012-11-17 15:06  132K  right foot signal
 park3.let               2012-11-17 15:06  132K  left foot signal
 park3.hea-              2000-11-07 12:55   57   header file
 park3.hea               2012-11-17 15:06  116   header file
 park2.ts                2000-11-07 12:55   24K  time series
 park2.rit               2012-11-17 15:06  132K  right foot signal
 park2.let               2012-11-17 15:06  132K  left foot signal
 park2.hea-              2000-11-07 12:55   57   header file
 park2.hea               2012-11-17 15:06  115   header file
 park15.ts               2000-11-07 12:56   20K  time series
 park15.rit              2012-11-17 15:06  132K  right foot signal
 park15.let              2012-11-17 15:06  132K  left foot signal
 park15.hea-             2000-11-07 12:56   62   header file
 park15.hea              2012-11-17 15:06  117   header file
 park14.ts               2000-11-07 12:56   24K  time series
 park14.rit              2012-11-17 15:06  132K  right foot signal
 park14.let              2012-11-17 15:06  132K  left foot signal
 park14.hea-             2000-11-07 12:56   59   header file
 park14.hea              2012-11-17 15:06  118   header file
 park13.ts               2000-11-07 12:56   21K  time series
 park13.rit              2012-11-17 15:06  132K  right foot signal
 park13.let              2012-11-17 15:06  132K  left foot signal
 park13.hea-             2000-11-07 12:56   59   header file
 park13.hea              2012-11-17 15:06  119   header file
 park12.ts               2000-11-07 12:56   21K  time series
 park12.rit              2012-11-17 15:06  132K  right foot signal
 park12.let              2012-11-17 15:06  132K  left foot signal
 park12.hea-             2000-11-07 12:56   59   header file
 park12.hea              2012-11-17 15:06  118   header file
 park11.ts               2000-11-07 12:56   20K  time series
 park11.rit              2012-11-17 15:06  132K  right foot signal
 park11.let              2012-11-17 15:06  132K  left foot signal
 park11.hea-             2000-11-07 12:56   62   header file
 park11.hea              2012-11-17 15:06  117   header file
 park10.ts               2000-11-07 12:56   25K  time series
 park10.rit              2012-11-17 15:06  132K  right foot signal
 park10.let              2012-11-17 15:06  132K  left foot signal
 park10.hea-             2000-11-07 12:56   59   header file
 park10.hea              2012-11-17 15:06  119   header file
 park1.ts                2000-11-07 12:55   21K  time series
 park1.rit               2012-11-17 15:06  132K  right foot signal
 park1.let               2012-11-17 15:06  132K  left foot signal
 park1.hea-              2000-11-07 12:55   57   header file
 park1.hea               2012-11-17 15:06  115   header file
 hunt9.ts                2000-11-07 12:54   23K  time series
 hunt9.rit               2012-11-17 15:06  132K  right foot signal
 hunt9.let               2012-11-17 15:06  132K  left foot signal
 hunt9.hea-              2000-11-07 12:54   57   header file
 hunt9.hea               2012-11-17 15:06  115   header file
 hunt8.ts                2000-11-07 12:54   22K  time series
 hunt8.rit               2012-11-17 15:06  132K  right foot signal
 hunt8.let               2012-11-17 15:06  132K  left foot signal
 hunt8.hea-              2000-11-07 12:54   59   header file
 hunt8.hea               2012-11-17 15:06  117   header file
 hunt7.ts                2000-11-07 12:54   20K  time series
 hunt7.rit               2012-11-17 15:06  132K  right foot signal
 hunt7.let               2012-11-17 15:06  132K  left foot signal
 hunt7.hea-              2000-11-07 12:54   56   header file
 hunt7.hea               2012-11-17 15:06  113   header file
 hunt6.ts                2000-11-07 12:54   23K  time series
 hunt6.rit               2012-11-17 15:06  132K  right foot signal
 hunt6.let               2012-11-17 15:06  132K  left foot signal
 hunt6.hea-              2000-11-07 12:54   56   header file
 hunt6.hea               2012-11-17 15:06  116   header file
 hunt5.ts                2000-11-07 12:54   23K  time series
 hunt5.rit               2012-11-17 15:06  132K  right foot signal
 hunt5.let               2012-11-17 15:06  132K  left foot signal
 hunt5.hea-              2000-11-07 12:54   59   header file
 hunt5.hea               2012-11-17 15:06  117   header file
 hunt4.ts                2000-11-07 12:54   23K  time series
 hunt4.rit               2012-11-17 15:06  132K  right foot signal
 hunt4.let               2012-11-17 15:06  132K  left foot signal
 hunt4.hea-              2000-11-07 12:54   56   header file
 hunt4.hea               2012-11-17 15:06  119   header file
 hunt3.ts                2000-11-07 12:54   20K  time series
 hunt3.rit               2012-11-17 15:06  132K  right foot signal
 hunt3.let               2012-11-17 15:06  132K  left foot signal
 hunt3.hea-              2000-11-07 12:54   56   header file
 hunt3.hea               2012-11-17 15:06  112   header file
 hunt20.ts               2000-11-07 12:55   21K  time series
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 hunt20.hea-             2000-11-07 12:55   59   header file
 hunt20.hea              2012-11-17 15:06  119   header file
 hunt2.ts                2000-11-07 12:54   19K  time series
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 hunt2.let               2012-11-17 15:06  132K  left foot signal
 hunt2.hea-              2000-11-07 12:54   56   header file
 hunt2.hea               2012-11-17 15:06  116   header file
 hunt19.ts               2000-11-07 12:55   21K  time series
 hunt19.rit              2012-11-17 15:06  132K  right foot signal
 hunt19.let              2012-11-17 15:06  132K  left foot signal
 hunt19.hea-             2000-11-07 12:55   59   header file
 hunt19.hea              2012-11-17 15:06  118   header file
 hunt18.ts               2000-11-07 12:55   22K  time series
 hunt18.rit              2012-11-17 15:06  132K  right foot signal
 hunt18.let              2012-11-17 15:06  132K  left foot signal
 hunt18.hea-             2000-11-07 12:55   59   header file
 hunt18.hea              2012-11-17 15:06  118   header file
 hunt17.ts               2000-11-07 12:55   21K  time series
 hunt17.rit              2012-11-17 15:05  132K  right foot signal
 hunt17.let              2012-11-17 15:05  132K  left foot signal
 hunt17.hea-             2000-11-07 12:55   59   header file
 hunt17.hea              2012-11-17 15:05  118   header file
 hunt16.ts               2000-11-07 12:55   16K  time series
 hunt16.rit              2012-11-17 15:04  132K  right foot signal
 hunt16.let              2012-11-17 15:04  132K  left foot signal
 hunt16.hea-             2000-11-07 12:55   59   header file
 hunt16.hea              2012-11-17 15:04  119   header file
 hunt15.ts               2000-11-07 12:55   19K  time series
 hunt15.rit              2012-11-17 15:04  132K  right foot signal
 hunt15.let              2012-11-17 15:04  132K  left foot signal
 hunt15.hea-             2000-11-07 12:55   59   header file
 hunt15.hea              2012-11-17 15:04  117   header file
 hunt14.ts               2000-11-07 12:55   22K  time series
 hunt14.rit              2012-11-17 15:04  132K  right foot signal
 hunt14.let              2012-11-17 15:04  132K  left foot signal
 hunt14.hea-             2000-11-07 12:55   60   header file
 hunt14.hea              2012-11-17 15:04  118   header file
 hunt13.ts               2000-11-07 12:55   14K  time series
 hunt13.rit              2012-11-17 15:04  132K  right foot signal
 hunt13.let              2012-11-17 15:04  132K  left foot signal
 hunt13.hea-             2000-11-07 12:55   60   header file
 hunt13.hea              2012-11-17 15:04  122   header file
 hunt12.ts               2000-11-07 12:55   22K  time series
 hunt12.rit              2012-11-17 15:04  132K  right foot signal
 hunt12.let              2012-11-17 15:04  132K  left foot signal
 hunt12.hea-             2000-11-07 12:55   59   header file
 hunt12.hea              2012-11-17 15:04  120   header file
 hunt11.ts               2000-11-07 12:54   20K  time series
 hunt11.rit              2012-11-17 15:04  132K  right foot signal
 hunt11.let              2012-11-17 15:04  132K  left foot signal
 hunt11.hea-             2000-11-07 12:54   60   header file
 hunt11.hea              2012-11-17 15:04  118   header file
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 hunt10.rit              2012-11-17 15:04  132K  right foot signal
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 hunt10.hea-             2000-11-07 12:54   60   header file
 hunt10.hea              2012-11-17 15:04  119   header file
 hunt1.ts                2000-11-07 12:54   27K  time series
 hunt1.rit               2012-11-17 15:04  132K  right foot signal
 hunt1.let               2012-11-17 15:04  132K  left foot signal
 hunt1.hea-              2000-11-07 12:54   56   header file
 hunt1.hea               2012-11-17 15:04  115   header file
 example-ts.ps           2000-11-07 12:13   33K  
 example-ts.png          2000-12-21 11:39   32K  
 control9.ts             2000-11-07 12:53   24K  time series
 control9.rit            2012-11-17 15:04  132K  right foot signal
 control9.let            2012-11-17 15:04  132K  left foot signal
 control9.hea-           2000-11-07 12:53   68   header file
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 control8.ts             2000-11-07 12:53   22K  time series
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 control6.ts             2000-11-07 12:53   23K  time series
 control6.rit            2012-11-17 15:04  132K  right foot signal
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 control6.hea-           2000-11-07 12:53   66   header file
 control6.hea            2012-11-17 15:04  123   header file
 control5.ts             2000-11-07 12:53   21K  time series
 control5.rit            2012-11-17 15:04  132K  right foot signal
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 control3.ts             2000-11-07 12:53   22K  time series
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 control3.let            2012-11-17 15:04  132K  left foot signal
 control3.hea-           2000-11-07 12:53   68   header file
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 control2.ts             2000-11-07 12:53   21K  time series
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 control16.ts            2000-11-07 12:54   21K  time series
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 als9.ts                 2000-11-07 12:52   18K  time series
 als9.rit                2012-11-17 15:04  132K  right foot signal
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 als9.hea-               2000-11-07 12:52   56   header file
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 als8.rit                2012-11-17 15:04  132K  right foot signal
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 als4.ts                 2000-11-07 12:52   12K  time series
 als4.rit                2012-11-17 15:04  132K  right foot signal
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 als3.ts                 2000-11-07 12:52   18K  time series
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 als2.ts                 2000-11-07 12:52   21K  time series
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 als2.hea-               2000-11-07 12:52   56   header file
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 als13.ts                2000-11-07 12:52   16K  time series
 als13.rit               2012-11-17 15:04  132K  right foot signal
 als13.let               2012-11-17 15:04  132K  left foot signal
 als13.hea-              2000-11-07 12:52   59   header file
 als13.hea               2012-11-17 15:04  117   header file
 als12.ts                2000-11-07 12:52   10K  time series
 als12.rit               2012-11-17 15:04  132K  right foot signal
 als12.let               2012-11-17 15:04  132K  left foot signal
 als12.hea-              2000-11-07 12:52   59   header file
 als12.hea               2012-11-17 15:04  119   header file
 als11.ts                2000-11-07 12:52   20K  time series
 als11.rit               2012-11-17 15:04  132K  right foot signal
 als11.let               2012-11-17 15:04  132K  left foot signal
 als11.hea-              2000-11-07 12:52   59   header file
 als11.hea               2012-11-17 15:04  115   header file
 als10.ts                2000-11-07 12:52   21K  time series
 als10.rit               2012-11-17 15:04  132K  right foot signal
 als10.let               2012-11-17 15:04  132K  left foot signal
 als10.hea-              2000-11-07 12:52   59   header file
 als10.hea               2012-11-17 15:04  116   header file
 als1.ts                 2000-11-07 12:52   17K  time series
 als1.rit                2012-11-17 15:04  132K  right foot signal
 als1.let                2012-11-17 15:04  132K  left foot signal
 als1.hea-               2000-11-07 12:52   56   header file
 als1.hea                2012-11-17 15:04  115   header file
 TEST.shtml              2016-09-23 15:44  9.5K  
 SHA256SUMS              2012-11-17 15:24   24K  
 SHA1SUMS                2012-11-17 15:24   17K  
 RECORDS                 2000-12-21 10:52  447   list of record names
 MD5SUMS                 2012-11-17 15:24   14K  
 DOI                     2015-09-21 13:00   19

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