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Please cite this publication when referencing this material, and also include the standard citation for PhysioNet:
Salt-sensitive hypertension is known to be associated with dysfunction of the baroreflex control system in the Dahl salt-sensitive (SS) rat. However, neither the physiological mechanisms nor the genomic regions underlying the baroreflex dysfunction seen in this rat model are definitively known. Here, we have adopted a mathematical modeling approach to investigate the physiological and genetic origins of baroreflex dysfunction in the Dahl SS rat. We have developed a computational model of the overall baroreflex heart rate control system based on known physiological mechanisms to analyze telemetry-based blood pressure and heart rate data from two genetic strains of rat, the SS and consomic SS.13BN, on low- and high-salt diets. With this approach, physiological parameters are estimated, unmeasured physiological variables related to the baroreflex control system are predicted, and differences in these quantities between the two strains of rat on low- and high-salt diets are detected. Specific findings include: a significant selective impairment in sympathetic gain with high-salt diet in SS rats and a protection from this impairment in SS.13BN rats, elevated sympathetic and parasympathetic offsets with high-salt diet in both strains, and an elevated sympathetic tone with high-salt diet in SS but not SS.13BN rats. In conclusion, we have associated several important physiological parameters of the baroreflex control system with chromosome 13 and have begun to identify possible physiological mechanisms underlying baroreflex impairment and hypertension in the Dahl SS rat that may be further explored in future experimental and modeling-based investigation.
Pressure-Time series Data
The four *.txt (text) files below contain continuous blood pressure recordings for 9 Dahl SS rats and 6 Dahl SS.13BN rats, under high and low salt conditions. Read the comments at the top of each file for details.
For convenience, the data contained in the original text files are also available in standard PhysioBank format, suitable for study using the PhysioBank ATM and the WFDB Software Package. Each pair of (binary) *.dat and (text) *.hea files below comprises a PhysioBank-format record that contains data from a single rat, extracted from the *.txt files.
Name Last modified Size Description
Parent Directory -
DOI 2015-09-21 13:00 19
RECORDS 2012-06-26 14:07 258 list of record names
SSBN13_HS.txt 2012-06-21 11:00 567K Dahl SSBN13 on high salt diet
SSBN13_LS.txt 2012-06-21 11:00 553K Dahl SSBN13 on low salt diet
SS_HS.txt 2012-06-21 10:59 844K Dahl SS on high salt diet
SS_LS.txt 2012-06-21 10:59 834K Dahl SS on low salt diet
ssbn13hs01.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13hs01.hea 2012-06-26 14:42 105 header file
ssbn13hs02.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13hs02.hea 2012-06-26 14:42 105 header file
ssbn13hs03.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13hs03.hea 2012-06-26 14:42 105 header file
ssbn13hs04.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13hs04.hea 2012-06-26 14:42 105 header file
ssbn13hs05.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13hs05.hea 2012-06-26 14:42 106 header file
ssbn13hs06.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13hs06.hea 2012-06-26 14:42 105 header file
ssbn13ls01.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13ls01.hea 2012-06-26 14:42 104 header file
ssbn13ls02.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13ls02.hea 2012-06-26 14:42 105 header file
ssbn13ls03.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13ls03.hea 2012-06-26 14:42 104 header file
ssbn13ls04.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13ls04.hea 2012-06-26 14:42 105 header file
ssbn13ls05.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13ls05.hea 2012-06-26 14:42 104 header file
ssbn13ls06.dat 2012-06-26 14:42 23K digitized signal(s)
ssbn13ls06.hea 2012-06-26 14:42 103 header file
sshs01.dat 2012-06-26 14:41 23K digitized signal(s)
sshs01.hea 2012-06-26 14:41 93 header file
sshs02.dat 2012-06-26 14:41 23K digitized signal(s)
sshs02.hea 2012-06-26 14:41 93 header file
sshs03.dat 2012-06-26 14:42 23K digitized signal(s)
sshs03.hea 2012-06-26 14:42 93 header file
sshs04.dat 2012-06-26 14:42 23K digitized signal(s)
sshs04.hea 2012-06-26 14:42 94 header file
sshs05.dat 2012-06-26 14:42 23K digitized signal(s)
sshs05.hea 2012-06-26 14:42 92 header file
sshs06.dat 2012-06-26 14:42 23K digitized signal(s)
sshs06.hea 2012-06-26 14:42 93 header file
sshs07.dat 2012-06-26 14:42 23K digitized signal(s)
sshs07.hea 2012-06-26 14:42 94 header file
sshs08.dat 2012-06-26 14:42 23K digitized signal(s)
sshs08.hea 2012-06-26 14:42 93 header file
sshs09.dat 2012-06-26 14:42 23K digitized signal(s)
sshs09.hea 2012-06-26 14:42 94 header file
ssls01.dat 2012-06-26 14:42 23K digitized signal(s)
ssls01.hea 2012-06-26 14:42 91 header file
ssls02.dat 2012-06-26 14:42 23K digitized signal(s)
ssls02.hea 2012-06-26 14:42 92 header file
ssls03.dat 2012-06-26 14:42 23K digitized signal(s)
ssls03.hea 2012-06-26 14:42 92 header file
ssls04.dat 2012-06-26 14:42 23K digitized signal(s)
ssls04.hea 2012-06-26 14:42 93 header file
ssls05.dat 2012-06-26 14:42 23K digitized signal(s)
ssls05.hea 2012-06-26 14:42 92 header file
ssls06.dat 2012-06-26 14:42 23K digitized signal(s)
ssls06.hea 2012-06-26 14:42 92 header file
ssls07.dat 2012-06-26 14:42 23K digitized signal(s)
ssls07.hea 2012-06-26 14:42 92 header file
ssls08.dat 2012-06-26 14:42 23K digitized signal(s)
ssls08.hea 2012-06-26 14:42 91 header file
ssls09.dat 2012-06-26 14:42 23K digitized signal(s)
ssls09.hea 2012-06-26 14:42 92 header file
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