Response to Valsalva Maneuver in Humans

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Version 1.0 - 12 November 2018

When referencing this material, please cite:

Kosinski SA, Carlson BE, Hummel SL, Brook RD, Beard DA. Computational Model-Based Assessment of Baroreflex Function from Response to Valsalva Maneuver. J Appl Physiol 2018 Sep 20. doi: 10.1152/japplphysiol.00095.2018. [Epub ahead of print].

Please also include the standard citation for PhysioNet:

Goldberger AL, Amaral LAN, Glass L, Hausdorff JM, Ivanov PCh, Mark RG, Mietus JE, Moody GB, Peng C-K, Stanley HE. PhysioBank, PhysioToolkit, and PhysioNet: Components of a New Research Resource for Complex Physiologic Signals. Circulation 101(23):e215-e220 [Circulation Electronic Pages; http://circ.ahajournals.org/content/101/23/e215]; 2000 (June 13). [bib]

@article{PhysioNet,
  author    = {Goldberger, Ary L. and Amaral, Luis A. N.
               and Glass, Leon and Hausdorff, Jeffrey M.
               and Ivanov, Plamen Ch. and Mark, Roger G.
               and Mietus, Joseph E. and Moody, George B.
               and Peng, Chung-Kang and Stanley, H. Eugene},
  title     = {{PhysioBank}, {PhysioToolkit}, and {PhysioNet}:
               Components of a New Research Resource for Complex
               Physiologic Signals},
  journal   = {Circulation},
  publisher = {American Heart Association, Inc.},
  volume    = {101},
  number    = {23},
  year      = {2000},
  month     = {June},
  pages     = {e215--e220},
  doi       = {10.1161/01.CIR.101.23.e215},
  issn      = {0009-7322},
  url       = {http://circ.ahajournals.org/content/101/23/e215}
}

Introduction

Functional metrics of autonomic control of heart rate, including baroreflex sensitivity, have been shown to be strongly associated with cardiovascular risk. A decrease in baroreflex sensitivity with aging is hypothesized to represent a contributing causal factor in the etiology of primary hypertension. To assess baroreflex function in human subjects, two complementary methods to simulate the response in heart rate elicited by the Valsalva maneuver were developed and applied to data obtained from a cohort of healthy normal volunteers.

Data Collection

Data was obtained from 27 participants excluding individuals with histories positive for inherited cardiomyopathy, valvular disease, aneurism, dissection, vascular surgery, pulmonary hypertension, connective tissue disease, or stroke. For each such normal healthy subject, baseline blood pressures were measured at 200 Hz during normal respiration prior to one or more instances of a forced expiration into a closed glottis (i.e Valsalva maneuver). The airway pressures achieved during expiration were measured at 10 Hz, with subjects instructed to maintain a pressure exceeding 30 mmHg for at least 10 seconds, though review of the data will show variability in each participant's results. Data collection of both blood and airway pressures continues throughout a recovery period subsequent to each Valsalva maneuver.

Files

The data for 27 subjects are presented here where for a given subject (e.g. norm001) two simultaneous recordings have been made. One is for the blood pressure obtained with a Finapres blood pressure monitor (e.g. norm001_BP) and the other is the thoracic pressure during three Valsalva maneuvers (e.g norm001_P). The thoracic pressure is measured by the subject breathing into a small closed chamber instrumented to measure the chamber pressure. The age and gender associated with each subject are found in the text file demographics.csv.

Contributors

This data was contributed by: Samuel A. Kosinski, Brian E. Carlson, Scott L. Hummel, Robert D. Brook and Daniel A. Beard.

Contact

For further information, please contact:

Brian Carlson
Department of Molecular and Integrative Physiology, University of Michigan
bcarl@umich.edu

Daniel Beard
Department of Molecular and Integrative Physiology, University of Michigan
beardda@umich.edu

 Name                    Last modified      Size  Description
 Parent Directory                             -   
 DOI                     2019-02-05 15:08   19   
 RECORDS                 2018-11-12 13:04  567   list of record names
 demographics.csv        2018-11-12 13:04  251   
 norm001_BP.dat          2018-11-12 13:04  112K  digitized signal(s)
 norm001_BP.hea          2018-11-12 13:04  178   header file
 norm001_P.dat           2018-11-12 13:04  5.6K  digitized signal(s)
 norm001_P.hea           2018-11-12 13:04  180   header file
 norm002_BP.dat          2018-11-12 13:04  100K  digitized signal(s)
 norm002_BP.hea          2018-11-12 13:04  178   header file
 norm002_P.dat           2018-11-12 13:04  5.0K  digitized signal(s)
 norm002_P.hea           2018-11-12 13:04  177   header file
 norm003_BP.dat          2018-11-12 13:04  102K  digitized signal(s)
 norm003_BP.hea          2018-11-12 13:04  176   header file
 norm003_P.dat           2018-11-12 13:04  5.1K  digitized signal(s)
 norm003_P.hea           2018-11-12 13:04  175   header file
 norm004_BP.dat          2018-11-12 13:04  107K  digitized signal(s)
 norm004_BP.hea          2018-11-12 13:04  178   header file
 norm004_P.dat           2018-11-12 13:04  5.3K  digitized signal(s)
 norm004_P.hea           2018-11-12 13:04  178   header file
 norm005_BP.dat          2018-11-12 13:04   80K  digitized signal(s)
 norm005_BP.hea          2018-11-12 13:04  176   header file
 norm005_P.dat           2018-11-12 13:04  4.0K  digitized signal(s)
 norm005_P.hea           2018-11-12 13:04  178   header file
 norm006_BP.dat          2018-11-12 13:04  109K  digitized signal(s)
 norm006_BP.hea          2018-11-12 13:04  177   header file
 norm006_P.dat           2018-11-12 13:04  5.4K  digitized signal(s)
 norm006_P.hea           2018-11-12 13:04  180   header file
 norm007_BP.dat          2018-11-12 13:04  206K  digitized signal(s)
 norm007_BP.hea          2018-11-12 13:04  179   header file
 norm007_P.dat           2018-11-12 13:04   10K  digitized signal(s)
 norm007_P.hea           2018-11-12 13:04  180   header file
 norm008_BP.dat          2018-11-12 13:04  292K  digitized signal(s)
 norm008_BP.hea          2018-11-12 13:04  179   header file
 norm008_P.dat           2018-11-12 13:04   15K  digitized signal(s)
 norm008_P.hea           2018-11-12 13:04  181   header file
 norm009_BP.dat          2018-11-12 13:04  232K  digitized signal(s)
 norm009_BP.hea          2018-11-12 13:04  178   header file
 norm009_P.dat           2018-11-12 13:04   12K  digitized signal(s)
 norm009_P.hea           2018-11-12 13:04  181   header file
 norm010_BP.dat          2018-11-12 13:04  103K  digitized signal(s)
 norm010_BP.hea          2018-11-12 13:04  178   header file
 norm010_P.dat           2018-11-12 13:04  5.2K  digitized signal(s)
 norm010_P.hea           2018-11-12 13:04  179   header file
 norm011_BP.dat          2018-11-12 13:04  168K  digitized signal(s)
 norm011_BP.hea          2018-11-12 13:04  178   header file
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 norm011_P.hea           2018-11-12 13:04  178   header file
 norm012_BP.dat          2018-11-12 13:04  238K  digitized signal(s)
 norm012_BP.hea          2018-11-12 13:04  177   header file
 norm012_P.dat           2018-11-12 13:04   12K  digitized signal(s)
 norm012_P.hea           2018-11-12 13:04  181   header file
 norm013_BP.dat          2018-11-12 13:04  184K  digitized signal(s)
 norm013_BP.hea          2018-11-12 13:04  176   header file
 norm013_P.dat           2018-11-12 13:04  9.2K  digitized signal(s)
 norm013_P.hea           2018-11-12 13:04  180   header file
 norm014_BP.dat          2018-11-12 13:04  117K  digitized signal(s)
 norm014_BP.hea          2018-11-12 13:04  176   header file
 norm014_P.dat           2018-11-12 13:04  5.8K  digitized signal(s)
 norm014_P.hea           2018-11-12 13:04  181   header file
 norm015_BP.dat          2018-11-12 13:04  135K  digitized signal(s)
 norm015_BP.hea          2018-11-12 13:04  178   header file
 norm015_P.dat           2018-11-12 13:04  6.7K  digitized signal(s)
 norm015_P.hea           2018-11-12 13:04  180   header file
 norm016_BP.dat          2018-11-12 13:04  348K  digitized signal(s)
 norm016_BP.hea          2018-11-12 13:04  178   header file
 norm016_P.dat           2018-11-12 13:04   17K  digitized signal(s)
 norm016_P.hea           2018-11-12 13:04  179   header file
 norm017_BP.dat          2018-11-12 13:04  353K  digitized signal(s)
 norm017_BP.hea          2018-11-12 13:04  179   header file
 norm017_P.dat           2018-11-12 13:04   18K  digitized signal(s)
 norm017_P.hea           2018-11-12 13:04  179   header file
 norm018_BP.dat          2018-11-12 13:04  263K  digitized signal(s)
 norm018_BP.hea          2018-11-12 13:04  178   header file
 norm018_P.dat           2018-11-12 13:04   13K  digitized signal(s)
 norm018_P.hea           2018-11-12 13:04  178   header file
 norm019_BP.dat          2018-11-12 13:04  181K  digitized signal(s)
 norm019_BP.hea          2018-11-12 13:04  177   header file
 norm019_P.dat           2018-11-12 13:04  9.1K  digitized signal(s)
 norm019_P.hea           2018-11-12 13:04  180   header file
 norm020_BP.dat          2018-11-12 13:04  287K  digitized signal(s)
 norm020_BP.hea          2018-11-12 13:04  178   header file
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 norm021_BP.dat          2018-11-12 13:04  313K  digitized signal(s)
 norm021_BP.hea          2018-11-12 13:04  177   header file
 norm021_P.dat           2018-11-12 13:04   16K  digitized signal(s)
 norm021_P.hea           2018-11-12 13:04  179   header file
 norm022_BP.dat          2018-11-12 13:04  553K  digitized signal(s)
 norm022_BP.hea          2018-11-12 13:04  178   header file
 norm022_P.dat           2018-11-12 13:04   28K  digitized signal(s)
 norm022_P.hea           2018-11-12 13:04  181   header file
 norm023_BP.dat          2018-11-12 13:04  260K  digitized signal(s)
 norm023_BP.hea          2018-11-12 13:04  179   header file
 norm023_P.dat           2018-11-12 13:04   13K  digitized signal(s)
 norm023_P.hea           2018-11-12 13:04  181   header file
 norm024_BP.dat          2018-11-12 13:04  237K  digitized signal(s)
 norm024_BP.hea          2018-11-12 13:04  178   header file
 norm024_P.dat           2018-11-12 13:04   12K  digitized signal(s)
 norm024_P.hea           2018-11-12 13:04  179   header file
 norm025_BP.dat          2018-11-12 13:04  193K  digitized signal(s)
 norm025_BP.hea          2018-11-12 13:04  178   header file
 norm025_P.dat           2018-11-12 13:04  9.7K  digitized signal(s)
 norm025_P.hea           2018-11-12 13:04  179   header file
 norm026_BP.dat          2018-11-12 13:04  221K  digitized signal(s)
 norm026_BP.hea          2018-11-12 13:04  178   header file
 norm026_P.dat           2018-11-12 13:04   11K  digitized signal(s)
 norm026_P.hea           2018-11-12 13:04  179   header file
 norm027_BP.dat          2018-11-12 13:04  369K  digitized signal(s)
 norm027_BP.hea          2018-11-12 13:04  178   header file
 norm027_P.dat           2018-11-12 13:04   18K  digitized signal(s)
 norm027_P.hea           2018-11-12 13:04  181   header file

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Updated Friday, 28 October 2016 at 16:58 EDT

PhysioNet is supported by the National Institute of General Medical Sciences (NIGMS) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under NIH grant number 2R01GM104987-09.